From the back cover:

FIRST CONTACT
'Alright, people, settle down. We haven't got a clue about what we're up against here. What we believe to be advance elements of their main fleet encountered one of our patrols yesterday morning. Friendly contact was lost, but not before we got an N-sweep of the aggressor vessels," the Ops Commander took a deep breath. "Configuration, unknown. Composition, unknown. Armaments, unknown. Occupants, unknown. Good tech, eh? What a surprise. What we do know is that they waxed our guys, and Deep Scan says more intruders are on the way. Plenty more, and soon. Questions?"
-Briefing segment

First Contact shows the initial confrontation with the Grubs, a bellicose alien race intent on the destruction of mankind. They swarm through deep space ravaging planet after planet. Night Brood: First Contact is a revision of the 1992 Night Brood Release.

Night Brood: First Contact includes:

• Rules for using Grub ships and weapons
• Night Brood scenarios
• Brood campaign guidelines
• 188 counters for Brood ships, Drones, Wormholes, and special equipment.
• Displays for 10 Brood ships
- Muskellunge
- Squidge
- Manta
- Dragonfly
- Shaggai
- Larva
- Lamprey
- Remora
- Tigermoth
- Thistle