Dominoes with the numbers replaced by musical notes and/or key signatures. The notes and/or key signatures must match to lay a tile.

An early version of Musical Dominoes was published by Theodore Dresser in 1893. C.W. Grimm was credited as the inventor. This set came with 36 dominoes marked with two equal squares in which note value signs ranging from a whole to a sixteenth were printed. The game came with two instruction booklets: "How to Play Musical Dominoes" and "How to Give Musical Domino Parties." The latter booklet explained six game variations.